In silico exploration of Red Sea Bacillus genomes for natural product biosynthetic gene clusters

Ghofran, Othoum, Bougouffa, Salim, Razali, Rozaimi, Bokhari, Ameerah, Alamoundi, Soha, Antunes, André, Gao, Xin, Hoehndorf, Robert, Arold, Stefan T, Gojobori, Takashi, Hirt, Heribert, Mijakovic, Vladimir B, Mijakovic, Ivan, Bajic, Vladimir B, Lafi, Feras F and Essack, Magbubah (2018) In silico exploration of Red Sea Bacillus genomes for natural product biosynthetic gene clusters. BMC Genomics, 19 (382). pp. 1-11. ISSN 1471-2164 DOI https://doi.org/10.1186/s12864-018-4796-5

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Abstract

The increasing spectrum of multidrug-resistant bacteria is a major global public health concern, necessitating discovery of novel antimicrobial agents. Here, members of the genus Bacillus are investigated asa potentially attractive source of novel antibiotics due to their broad spectrum of antimicrobial activities. We specifically focus on a computational analysis of the distinctive biosynthetic potential of Bacillus paralicheniformis strains isolated from the Red Sea, an ecosystem exposed to adverse, highly saline and hot conditions.

Item Type: Article
Subjects: R Medicine > R Medicine (General)
Divisions: Biology
Date Deposited: 24 May 2018 10:12
URI: http://repository.edgehill.ac.uk/id/eprint/10367

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