On drug-base incompatibilities during extrudate manufacture and fused deposition 3D printing

Davies, Michael, Costley, Emily, Ren, James, Gibbons, Paul, Konodor, Annett and Naderi, Majid (2016) On drug-base incompatibilities during extrudate manufacture and fused deposition 3D printing. Journal of 3D Printing in Medicine, 1 (1). pp. 1-17. ISSN 2059-4755 DOI https://doi.org/10.2217/3dp-2016-0006

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Abstract

Aim: 3D printing can be applied for point-of-care personalized treatment. This study aimed to determine the manufacturability and characteristics of 3D printed, drug-loaded implants for alcohol misuse. Materials & methods: Disulfiram was the drug substance used and polylactic acid (PLA) the base material. Implantable devices were designed in silico. Drug and PLA were placed into the extruder to produce a 5% blend at 1.75-mm diameter. Material characterization included differential scanning calorimetry, thermogravimetric analysis plus inverse GC-surface energy analyzer. Results: Implantable constructs from the PLA feedstock were acquired. The extrusion processes had a detrimental effect on the active pharmaceutical ingredient-base blend. differential scanning calorimetry and thermogravimetric analysis analysis indicated drug–base interactions. Thermal history was found to influence inverse GC probe interaction. Conclusion: Drug-base incompatibilities must be considered during 3D printing.

Item Type: Article
Uncontrolled Keywords: 3D printing, active, alcohol misuse, disulfiram, incompatibilities, materials characterization, polyactic acid
Subjects: R Medicine > R Medicine (General)
R Medicine > RT Nursing
Divisions: Nursing and Midwifery
Date Deposited: 15 Aug 2018 14:14
URI: http://repository.edgehill.ac.uk/id/eprint/10542

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