Effect of N-acetyl cysteine (NAC) Supplementation on Positive and Negative Syndrome Scale in Schizophrenia: A Systematic Review and Meta-Analysis of Randomised Controlled Trials

Ghaderi, Amir, Bussu, Anna, Tsang, Catherine and Jafarnejad, Sadegh (2018) Effect of N-acetyl cysteine (NAC) Supplementation on Positive and Negative Syndrome Scale in Schizophrenia: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. European Journal of Clinical Pharmacology. ISSN 0031-6970 DOI https://doi.org/10.1007/s00228-018-2595-1

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Abstract

Overview Stats Comments Citations References (56) Related research (10+) Abstract Objective To conduct a systematic review and meta-analysis of published randomised controlled trials on the efficacy of NAC supplementation on positive and negative syndrome scale in schizophrenia. Methods A meta-analysis was conducted, and studies were identified by a search of electronic databases from inception to May 2018. Combined and stratified analyses were used. Results Seven trials were identified, and data from n = 447 participants were included. Pooled analysis showed improvement of positive and negative syndrome scale following NAC treatment compared with placebo, for total (SMB = − 0.96) [95% CI − 1.69, − 0.24; P = 0.009], general (SMB = − 1.04) [95% CI − 1.80, − 0.27; P = 0.008] and negative (SMB = − 0.73) [95% CI − 1.29, − 0.17; P = 0.01] scores, respectively. Significant heterogeneity was found, and subgroup analysis showed significant reductions in studies with a treatment duration of ≤ 24 weeks, with a considerable effect size on total, general, and negative scores (Total SMD = − 0.83; General SMD = − 0.67; Negative SMD = − 1.09) following NAC. Conclusions NAC improved all aspects of positive and negative syndrome scale in schizophrenic populations and may be more efficacious with treatment durations up to 24 weeks.

Item Type: Article
Uncontrolled Keywords: N-acetyl cysteine, Schizophrenia, PANSS, Meta-analysis
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Nursing and Midwifery
Date Deposited: 19 Nov 2018 11:40
URI: http://repository.edgehill.ac.uk/id/eprint/10850

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