Patients' health-related quality of life and utilities associated with different stages of amyotrophic lateral sclerosis.

Kiebert, G., Green, C., Murphy, C., Mitchell, J., O'Brien, M., Burrell, A. and Leigh, P. (2001) Patients' health-related quality of life and utilities associated with different stages of amyotrophic lateral sclerosis. Journal of the Neurological Sciences, 191 (1-2). pp. 87-93. ISSN 0022510X DOI https://doi.org/10.1016/S0022-510X(01)00616-5

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Abstract

Objectives: Amyotrophic lateral sclerosis (ALS) is a devastating disease that has serious consequences in terms of impairments and disabilities, which are expected to impact on health-related quality of life (HRQL). The aim of the present study was to assess self-reported health status and HRQL, as well as patients' own valuation of their present health state in a sample of patients with different levels of severity of ALS. Methods: Structured interviews were conducted with 77 patients with different levels of disease severity. Patients completed a disease-specific health status measure (ALSAQ-40), a generic health status measure (EuroQol EQ-5D), visual analogue scale (VAS) rating of current health and a standard gamble (SG) exercise to provide health state utilities for their own health state. Results: The results from the ALSAQ-40 and EQ-5D descriptive system indicate that patients' HRQL decreases systematically with increasing severity of disease. Patients' mean VAS rating of their own health ranged from 0.74 for stage 1 (early) disease severity, to 0.37 for stage 4 (late stage) disease severity. Utilities elicited via SG were systematically higher than VAS scores and ranged from a mean of 0.79 for stage 1 disease severity to a mean of 0.45 for stage 4 disease severity.

Item Type: Article
Uncontrolled Keywords: PMED ID13677501 Health-related quality of life, Utilities, Amyotrophic lateral sclerosis
Subjects: R Medicine > R Medicine (General)
Divisions: Nursing and Midwifery
Date Deposited: 25 Mar 2010 13:34
URI: http://repository.edgehill.ac.uk/id/eprint/130

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