School age outcome of hospitalisation with respiratory syncytial virus infection of prematurely born infants

Greenough, A, Alexander, J, Boit, P, Boorman, J, Burgess, S, Burke, A, Chetcuti, P A, Cliff, I, Lenney, W, Lytle, T, Morgan, C, Raiman, C, Shaw, N J, Sylvester, K P and Turner, J (2009) School age outcome of hospitalisation with respiratory syncytial virus infection of prematurely born infants. Thorax, 64 (6). pp. 490-495. ISSN 0040-6376 DOI https://doi.org/10.1136/thx.2008.095547

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Abstract

Background: Hospitalisation due to respiratory syncytial virus (RSV) infection in the first 2 years after birth has been associated with increased healthcare utilisation and associated costs up to 5 years of age in children born prematurely at less than 32 weeks of gestation who developed bronchopulmonary dysplasia (BPD). A study was undertaken to determine whether hospitalisation due to RSV infection in the first 2 years was associated with increased morbidity and lung function abnormalities in such children at school age, and if any effects were influenced by age. Methods: Healthcare utilisation and cost of care in years 5–7 were reviewed in 147 children and changes in healthcare utilisation between 0 and 8 years were assessed also using results from two previous studies. At age 8–10 years, 77 children had their lung function assessed and bronchial hyper-responsiveness determined. Results: Children hospitalised with RSV infection (n = 25) in the first 2 years had a greater cost of care related to outpatient attendance than those with a non-respiratory or no admission (n = 72) when aged 5–7 years (p = 0.008). At 8–10 years of age, children hospitalised with RSV infection (n = 14) had lower forced expiratory volume in 0.75 s (FEV0.75) (p = 0.015), FEV0.75/forced vital capacity (p = 0.027) and flows at 50% (p = 0.034) and 75% (p = 0.006) of vital capacity than children hospitalised for non-RSV causes (n = 63). Healthcare utilisation decreased with increasing age regardless of RSV hospitalisation status. Conclusions: In prematurely born children who had BPD, hospitalisation due to RSV infection in the first 2 years is associated with reduced airway calibre at school age.

Item Type: Article
Subjects: R Medicine > RB Pathology
R Medicine > RJ Pediatrics
Divisions: Nursing and Midwifery
Date Deposited: 15 Mar 2011 16:26
URI: http://repository.edgehill.ac.uk/id/eprint/2751

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