Variation in basal heat shock protein 70 is correlated to core temperature in human subjects

Sandstrom, M E, Madden, L A, Taylor, L, Siegler, J C, Lovell, R J, Midgley, A and McNaughton, Lars (2009) Variation in basal heat shock protein 70 is correlated to core temperature in human subjects. Amino Acids, 37 (2). pp. 279-284. ISSN 0939-4451 DOI https://doi.org/10.1007/s00726-008-0144-4

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Abstract

Heat shock proteins are highly conserved proteins and play an important chaperone role in aiding the folding of nascent proteins within cells. The heat shock protein response to various stressors, both in vitro and in vivo, is well characterised. However, basal levels of heat shock protein 70 (Hsp70) have not previously been investigated. Monocyte-expressed Hsp70 was determined every 4 h, over a 24 h time period, in 17 healthy male subjects (177 ± 6.4 cm, 75.7 ± 10.9 kg, 19.8 ± 4.3 years) within a temperature and activity controlled environment. Core temperature was measured at 5-min intervals during the 24 h period. Hsp70 showed significant diurnal variation (F = 7.4; p < 0.001), demonstrating peaks at 0900 and 2100 hours, and a nadir at 05.00. Core temperature followed a similar temporal trend (range = 35.96–38.10°C) and was significantly correlated with Hsp70 expression (r s = 0.44; p < 0.001). These findings suggest a high responsiveness of Hsp70 expression in monocytes to slight variations in core temperature.

Item Type: Article
Subjects: Q Science > QP Physiology
R Medicine > RC Internal medicine > RC1200 Sports Medicine
Divisions: Sports Science
Date Deposited: 30 Jul 2012 15:39
URI: http://repository.edgehill.ac.uk/id/eprint/4034

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