Differential expression of the detoxification genes in the different life stages of the malaria vector Anopheles gambiae.

Strode, Clare, Steen, K, Ortelli, F and Ranson, H (2006) Differential expression of the detoxification genes in the different life stages of the malaria vector Anopheles gambiae. Insect molecular biology, 15 (4). pp. 523-30. ISSN 0962-1075 DOI https://doi.org/10.1111/j.1365-2583.2006.00667.x

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Abstract

The diverse habitats and diets encountered during the life cycle of an Anopheles mosquito have necessitated the development of extensive families of detoxification enzymes. Expansion of the three detoxification enzyme families (cytochrome P450s, carboxylesterases and glutathione transfereases), has occurred in mosquitoes compared with Drosophila, however, very little is known regarding the developmental expression of theses genes. Using a custom made microarray we determined the expression profile of the detoxification genes in adults, larvae and pupae of the malaria vector A. gambiae. The expression of approximately one quarter of these genes was developmentally regulated. The expression profile of each of these genes and the information this data provides on putative functions of the mosquito detoxification enzymes is discussed.

Item Type: Article
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QH Natural history > QH426 Genetics
Divisions: Biology
Date Deposited: 17 Mar 2016 10:48
URI: http://repository.edgehill.ac.uk/id/eprint/7308

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