Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation.

Fürstenberger, Gerhard, Epp, Nikolas, Eckl, Katja-Martina, Hennies, Hans Christian, Jørgensen, Claus, Hallenborg, Philip, Kristiansen, Karsten and Krieg, Peter (2007) Role of epidermis-type lipoxygenases for skin barrier function and adipocyte differentiation. Prostaglandins & other lipid mediators, 82 (1-4). pp. 128-34. ISSN 1098-8823 DOI https://doi.org/10.1016/j.prostaglandins.2006.05.006

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Abstract

12R-lipoxygenase (12R-LOX) and epidermis-type LOX-3 (eLOX-3) are novel members of the multigene family of mammalian LOX. A considerable gap exists between the identification of these enzymes and their biologic function. Here, we present evidence that 12R-LOX and eLOX-3, acting in sequence, and eLOX-3 in combination with another, not yet identified LOX are critically involved in terminal differentiation of keratinocytes and adipocytes, respectively. Mutational inactivation of 12R-LOX and/or eLOX-3 has been found to be associated with development of an inherited ichthyosiform skin disorder in humans and genetic ablation of 12R-LOX causes a severe impairment of the epidermal lipid barrier in mice leading to post-natal death of the animals. In preadipocytes, a LOX-dependent PPARgamma activating ligand is released into the cell supernatant early upon induction of differentiation and available evidence indicates that this ligand is an eLOX-3-derived product. In accordance with this data is the observation that forced expression of eLOX-3 enhances adipocyte differentiation.

Item Type: Article
Subjects: Q Science > QP Physiology
R Medicine > RL Dermatology
Date Deposited: 04 May 2016 10:36
URI: http://repository.edgehill.ac.uk/id/eprint/7684

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